Title
Reese’s Blu-Tabs (Ephedrine Sulfate Nasal Decongestant)
Author
The Reese Chemical Co., Cleveland, Ohio
Image
Description
This colorful mid-century box and glass vial contain Reese’s Blu-Tabs, an over-the-counter medication designed for the relief of nasal congestion, hay fever, rose fever, head colds, and non-cardiac asthma attacks. The bright blue tablets were produced by The Reese Chemical Company of Cleveland, Ohio, and came 36 to a box.
The active ingredients include:
Ephedrine Sulfate (1/8 grain) – a bronchodilator and decongestant
Ortho-iodo-benzoic acid – likely used for its antiseptic or anti-inflammatory properties
Calcium Lactate – a common supplement additive
The side of the package carries detailed directions and multiple health warnings, including cautions for those with heart disease, high blood pressure, or toxic goiter, underscoring the stimulant potential of ephedrine.
Condition
The original box is intact with vibrant yellow and blue graphics and “RC” monogramming. The glass bottle remains sealed, filled with distinctive blue-coated tablets. Minor wear and discoloration are present on the box and cap, consistent with age.
Gallery
Historical context
Ephedrine, derived from the ephedra plant, was widely used in the early-to-mid 20th century as a nasal decongestant and bronchodilator. By the time Reese’s Blu-Tabs were on the market (likely 1940s–1960s), ephedrine was a popular ingredient in cold medications, weight loss pills, and asthma treatments.
Over time, its stimulant properties led to stricter regulation due to its potential for misuse and its role as a precursor in the manufacture of methamphetamine. Medications like this—once available over the counter—eventually became more tightly controlled.
Curious Facts, Ephemera, and Trivia
The striking blue color of the tablets and packaging was likely chosen for branding, but evokes modern cold remedies like Sudafed or Vicks.
“Blu-Tabs” is not just a product name—it reflects the literal bluish candy-like coating that was common in midcentury pill design.
Reese Chemical Co. also marketed other over-the-counter meds under the “RC” logo, but Blu-Tabs remain their most visually memorable.
Excerpt
“For the relief of nasal congestion of hay fever, rose fever and head colds. Also relief of asthma paroxysms of non-cardiac nature.”
— Reese’s Blu-Tabs box, directions panel
Why it is in the Cabinet
This piece is a striking visual and historical specimen of mid-century pharmaceutical marketing and over-the-counter treatment trends. It highlights the pre-regulation era of cold medications—when powerful substances like ephedrine were sold in candy-colored pills at the corner drugstore.
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